Z79.818 Long term (current) use of other agents affecting estrogen receptors and estrogen levels

Coding notes

From the ICD-10-CM FY2027 (effective October 1, 2026) tabular list. Notes on a parent code or category apply here too.

Also covers

• Long term (current) use of estrogen receptor downregulators
• Long term (current) use of fulvestrant (Faslodex)
• Long term (current) use of gonadotropin-releasing hormone (GnRH) agonist
• Long term (current) use of goserelin acetate (Zoladex)
• Long term (current) use of leuprolide acetate (leuprorelin) (Lupron)
• Long term (current) use of megestrol acetate (Megace)

Includes

• long term (current) drug use for prophylactic purposes

Excludes1

Not coded together with this code. The exception is when the two conditions are unrelated to each other.

• hormone replacement therapy (Z79.890)

Excludes2

Not part of this code, but both can be coded when both are documented.

• drug abuse and dependence (F11-F19)
• drug use complicating pregnancy, childbirth, and the puerperium (O99.32-)

Code first

Code the underlying condition first, then this code.

• , if applicable:
• malignant neoplasm of breast (C50.-)
• malignant neoplasm of prostate (C61)

Use additional code

Add a second code for the following, when documented.

• code, if applicable, to identify:
• estrogen receptor positive status (Z17.0)
• family history of breast cancer (Z80.3)
• genetic susceptibility to malignant neoplasm (cancer) (Z15.0-)
• personal history of breast cancer (Z85.3)
• personal history of prostate cancer (Z85.46)
• postmenopausal status (Z78.0)

Code also

A second code may be needed. Sequencing depends on the encounter.

• any therapeutic drug level monitoring (Z51.81)
• any follow-up examination (Z08-Z09)